N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-L-phenylalanine
BOC-L-2-Methylphe
CAS: 114873-05-1
Molecular Formula: C15H21NO4
N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-L-phenylalanine - Names and Identifiers
| Name | BOC-L-2-Methylphe |
| Synonyms | Boc-L-2-CH3-Phe Boc-Phe(2-Me)-OH BOC-L-2-Methylphe RARECHEM BK PT 0056 Boc-L-2-Methylphenylalanine Boc-2-Methyl-L-phenylalanine tert-butoxycarbonyl-l-2-methylphenylalanine (S)-Boc-2-amino-3-(2-methylphenyl)propionic acid N-ALPHA-T-BUTOXYCARBONYL-L-(2-METHYLPHENYL)ALANINE (S)-2-TERT-BUTOXYCARBONYLAMINO-3-O-TOLYL-PROPIONIC ACID N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-L-phenylalanine |
| CAS | 114873-05-1 |
| InChI | InChI=1/C15H21NO4/c1-10-7-5-6-8-11(10)9-12(13(17)18)16-14(19)20-15(2,3)4/h5-8,12H,9H2,1-4H3,(H,16,19)(H,17,18)/t12-/m1/s1 |
N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-L-phenylalanine - Physico-chemical Properties
| Molecular Formula | C15H21NO4 |
| Molar Mass | 279.33 |
| Density | 1.140±0.06 g/cm3(Predicted) |
| Melting Point | 113°C |
| Boling Point | 442.5±40.0 °C(Predicted) |
| Specific Rotation(α) | -16 º (c=1,MeOH) |
| Flash Point | 221.4°C |
| Vapor Presure | 1.31E-08mmHg at 25°C |
| BRN | 5381790 |
| pKa | 3.92±0.11(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.526 |
| MDL | MFCD00671390 |
| Physical and Chemical Properties | Melting point 113°C specific optical rotation -16 ° (c = 1,MeOH) |
N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-L-phenylalanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
N-[(1,1-Dimethylethoxy)carbonyl]-2-methyl-L-phenylalanine - Introduction
BOC-L-2-Methylphenylalanine is an organic compound whose chemical formula is C17H25NO4. The following is a description of its nature, use, preparation and safety information:
Nature:
BOC-L-2-Methylphenylalanine is a white crystalline solid with a distinctive odor. It is insoluble in water at normal temperature, but soluble in some organic solvents such as ethanol and dimethyl sulfoxide.
Use:
BOC-L-2-methylphenylalanine is commonly used as a synthetic intermediate in organic synthesis. It can participate in a variety of reactions, such as esterification, acylation and amination reactions. In the pharmaceutical field, it is also commonly used as an amino acid protecting group and solid phase deprotection reagent.
Method:
There are many methods for the synthesis of BOC-L-2-methylphenylalanine. One commonly used method is to react 2-methylphenylpropionic acid with BOC-2-amino-4-methylphenylacetic anhydride. The reaction is carried out in an organic solvent at room temperature for a period of time and then the product is obtained by crystallization.
Safety Information:
BOC-L-2-Methylphenylalanine is an organic compound with a certain degree of risk. Observe the necessary safety measures during operation, such as wearing protective glasses and gloves to ensure a well-ventilated working environment. In addition, care should be taken to prevent contact with oxidants and strong acids to avoid dangerous reactions. During storage and transportation, it should be kept sealed and away from fire and high temperature environment.
Nature:
BOC-L-2-Methylphenylalanine is a white crystalline solid with a distinctive odor. It is insoluble in water at normal temperature, but soluble in some organic solvents such as ethanol and dimethyl sulfoxide.
Use:
BOC-L-2-methylphenylalanine is commonly used as a synthetic intermediate in organic synthesis. It can participate in a variety of reactions, such as esterification, acylation and amination reactions. In the pharmaceutical field, it is also commonly used as an amino acid protecting group and solid phase deprotection reagent.
Method:
There are many methods for the synthesis of BOC-L-2-methylphenylalanine. One commonly used method is to react 2-methylphenylpropionic acid with BOC-2-amino-4-methylphenylacetic anhydride. The reaction is carried out in an organic solvent at room temperature for a period of time and then the product is obtained by crystallization.
Safety Information:
BOC-L-2-Methylphenylalanine is an organic compound with a certain degree of risk. Observe the necessary safety measures during operation, such as wearing protective glasses and gloves to ensure a well-ventilated working environment. In addition, care should be taken to prevent contact with oxidants and strong acids to avoid dangerous reactions. During storage and transportation, it should be kept sealed and away from fire and high temperature environment.
Last Update：2024-04-10 22:29:15
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